Incidentally Detected Celiac Disease with Splenomegaly on ۱۸F FDG PET/CT: A Potential Lymphoma Mimic
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JNMB-9-1_008
تاریخ نمایه سازی: 14 اردیبهشت 1400
Abstract:
Celiac disease is an immune-mediated disorder triggered by hypersensitivity to gluten occurring in genetically susceptible individuals. A high-index of suspicion is needed for diagnosis as patients can be asymptomatic or present with atypical symptoms or extra-intestinal manifestations. Typical ۱۸F-Fluorodeoxyglucose (FDG) Positron Emission Tomography (PET)/Computed Tomography (CT) gastrointestinal manifestations of celiac disease include increased multifocal or diffuse jejunal and ileal uptake; focal duodenal uptake is less common. Splenomegaly with increased splenic FDG uptake is also uncommon in celiac disease in the absence of portal hypertension; small-sized spleen and functional hyposplenism are more typical. We report a case of celiac disease diagnosed after PET/CT showed FDG uptake in the duodenum and enlarged spleen. Follow-up after gluten-free diet showed complete metabolic resolution and regression of splenomegaly. The combination of focal bowel and splenic uptake is unusual in celiac disease and may be mistaken for a lymphoproliferative disorder. Awareness of this entity may avoid misdiagnosis and guide appropriate management.
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Authors
Ananya Panda
Departments of Radiology, Mayo Clinic, Rochester, Minnesota, USA
Michael McCarthy
Departments of Pathology, Mayo Clinic, Rochester, Minnesota, USA
Joseph Murray
Departments of Gastroenterology, Mayo Clinic, Rochester, Minnesota, USA
Rosalind Sharain
Departments of Pathology, Mayo Clinic, Rochester, Minnesota, USA
Min Shi
Departments of Pathology, Mayo Clinic, Rochester, Minnesota, USA
Ayse Kendi
Departments of Radiology, Mayo Clinic, Rochester, Minnesota, USA
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