Effect of diabetes mellitus on a specific LncRNA in Hippocampus and Prefrontal cortex

Background and Aim: Diabetes mellitus is a huge and well-known problem in all over the world that is defined as a heterogeneous disorder. Type ۱ diabetes (T۱D) is a complex autoimmune disease that is denoted by the destruction of pancreatic beta cells and insulin-deficient hyperglycemia and is considered the leading cause of morphological and structural dysfunctions in the nervous system such as deficient memory and learning. Two main regions of the brain involved in memory and learning process namely the Hippocampus and Pre-frontal cortex. T۱D give rise to create an important deficit in crucial process related to memory and learning such as proliferation, synaptic plasticity, and apoptosis. These kinds of functions link to a wider range of genres such as LncRNAs. Long non-coding RNAs are transcribed by RNA polymerases II and III), which are longer than ۲۰۰ nucleotides and constitute ۹۷– ۹۸% of the human genome that is not translated into proteins. In previous studies, the special lncRNAs were determined in HP and PFC regions of C۵۷BL miceMethods: C۵۷BL mice induced type ۱ diabetes and performed physiological and molecular tests such as PCR and Real-Time. finally, the statical test considered for finding the measurement of changes in lncRNA.Results: We observed a remarkable change in the expression of interest lncRNA in the diabetic group Conclusion: which is concluded that LncRNA may have a role in memory and learning in mice.

Keywords:

diabetes mellitus , LncRNA , mice , memory , learning