Comparative phylogenetic evaluation of wound healing mechanisms in some organisms

Background and Aim: Doubtless strategies that can help accelerate wound healing are certainly one of the major challenges in the biomedical field. Recognition the mechanisms and main patterns of wound healing in organisms that are known to rapidly heal tissue, can help science design new therapeutic strategies.Methods: In the present study, we first identified paralog genes for FGF, VEGF, NGF, EGF, LIF, and sdfI molecules in three marker organisms in terms of wound healing including earthworm, starfish and gecko; And after identifying these genes in the marker organisms, we designed the relevant gene networks and compared them with humans. The promoter regions of the above genes were also compared between the studied species.Results: The results show some phylogenetic convergence between some of the studied genes, notably NGF and FGF. In cases like sdf, the gene marker is more active in humans and closer species. There were also significant differences in the promoter regions of the above genes.Conclusion: The differences in the promoter regions of the NGF and FGF genes may support the hypothesis that in some of the marker species the expression level of these genes plays a key role in the healing.

Keywords:

Phylogenetic analysis , Gene network , Wound healing