In Silico Analysis of Noncoding SNPs of Human FOXD۳ Gene and their effects on protein functions

Publish Year: 1399
نوع سند: مقاله کنفرانسی
زبان: English
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CIGS16_165

تاریخ نمایه سازی: 14 اردیبهشت 1400

Abstract:

Background and Aim: FOXD۳ (Gensis/HF۲) is an important member of FOX family that is a transcriptional repressor in the carcinogenesis of many cancers via MAPK/ERK signaling pathway. Single nucleotide polymorphisms (SNPs) can disrupt in tumor suppressor function of FOXD۳. In this study, we have analyzed the non-coding SNPs of FOXD۳ that can alter the function of this gene in cancer and disease by, using “in silico” approach.Methods: we explored in the miRNA SNP database, and found three SNPs in ۳ﹶ-UTR that can disrupt interaction of FOXD۳ mRNA with miRNAs (gain or loss). we know that there are nine common SNPs in FOXD۳ by using the UCSC genome browser. Using on the SNP۲TFBS database show that, one SNP (rs۷۸۶۴۵۴۷۹) among nine common SNPs can affect binding site. In addition, UTRdb served to identify five important SNPs in the ۳ﹶ-UTR of FOXD۳ mRNA that predicted to be changed polyadenylation region.Results: Thus, funding of this study indicate, SNPs in non-coding region of FOXD۳ gene can alter protein function. FOXD۳ dysfunction may decrease its suppressor effect on cancers.Conclusion: It is proposed that, exploring in genetic variation and SNPs can be a novel marker for prognostic of various disease spatially cancers.

Authors

Mahboobeh Zarei

hormozgan medical science university

pegah mousavi

hormozgan medical science university