Association of HLA-DRA gene with Non-obstructive azoospermia in Iranian infertile men

Background and Aim: Azoospermia is diagnosed when sperm cells are completely absent in the ejaculate even after centrifugation. It is identified in approximately ۱% of all men and in ۱۰%–۲۰% of infertile males. Non-obstructive azoospermia (NOA) is characterized by the absence of sperm in the ejaculate without obstruction of the reproductive tract pathway. In this study, the relationship between a SNP of HLA-DRA with NOA in Iranian infertile men was investigated.Methods: PCR was used for genotyping of SNP responsible for the NOA in Iranian infertile men. One hundred genomic DNA samples of patients and one hundred genomic DNA of impatient (control) were obtained from ROYAN Institute in Tehran, Iran.Results: Significant differences in allele distribution between fertile and sub-/infertile men were found (p=۰.۰۸).Conclusion: we provided evidence that the analyzed HLA-DRA variant is not associated with non-obstructive azoospermia in Iranian infertile men.