A novel non-coding RNA in pancreatic cancer

Background and Aim: Pancreatic cancer is the fourth most common cause of cancer deaths. Pancreatic cancer is hardly discovered until serious clinical symptoms appear, consequently, early diagnosis and detection of pancreatic cancer is a clinical challenge. Long non-coding RNAs (lncRNAs) have been recently reported to participate in the regulation of oxidative stress. Here, we examined the expression levels of lncRNA SCAL۱ in patients with pancreatic cancer compared with healthy subjects.Methods: In this study, the expression levels of lncRNA SCAL۱ were evaluated in ۳۰ patients with pancreatic cancer and ۳۰ healthy subjects with a Real-time PCR method.Results: The relative level of lncRNA SCAL۱ was significantly higher in patients with pancreatic cancer compared to healthy controls. Moreover, we found some significant correlations between lncRNA expression levels and clinical data of patients with pancreatic cancer.Conclusion: Our results highlight the role of this lncRNA in the oxidation/antioxidant system which may be helpful for the further investigation of specific biomarkers of pancreatic cancer. However, the specific molecular mechanisms and biological functions of this lncRNA need further study.

Keywords:

pancreatic cancer , miRNAs , long non coding RNAs , biomarker