The role of HERV and EMT in the development of breast cancer

Publish Year: 1399
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:

CIGS16_277

تاریخ نمایه سازی: 14 اردیبهشت 1400

Abstract:

Background and Aim: Breast cancer is the most frequent malignancy in women worldwide and is curable in ~۷۰–۸۰% of patients with early- stage, non- metastatic disease . Endogenous retroviruses (ERVs) are remnants of ancient retroviral infections that make up ۸% of the human genome. Although these elements are mostly fragmented and inactive, many proviruses belonging to the HERV-K (HML-۲) family have intact open reading frames, some encoding for accessory genes called np۹ and rec that interact with oncogenic pathways.Methods: In this study, we collected on ۴۲ pairs of breast carcinoma and their adjacent normal tissues. After RNA extraction and cDNA synthesis , quantitative Real Time PCR were performed for Snail and np۹ genes. Statistical analysis were performed using SPSS software.Results: Increased expression of Snail and np۹ genes was observed in tumor samples compared to non-tumors sample.Conclusion: Our results may imply that increased expression of Snail and np۹ genes has an important role in breast cancer pathogenesis.

Authors

Mahdieh Miralimalek

Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Rahmatiyeh, Shahrekord, Iran

Hossein Teimori

Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Rahmatiyeh, Shahrekord, Iran

Modjtaba Emadi-Baygi

Departnan OF Genetics , Faculty of Basic Sciences , Shahrekord University, Shahrekord, Iran