Assessment performance of immune systems and genetics factors in patients with cardiovascular disease

Publish Year: 1399
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:

CIGS16_292

تاریخ نمایه سازی: 14 اردیبهشت 1400

Abstract:

Background and Aim: The cardiovascular diseases are one of the most common causes of the deaths that occurred in developing countries and also they can cause one-third of all deaths in Iran and other countries throughout the world. The risk factors for cardiovascular diseases are divided into two categories; the variable risk factors and the non-variable risk factors. The variables are high blood pressure, hyperlipidemia, diabetes mellitus, smoking, sedentary life, obesity, stress, etc. while the non-variables include the males, elders, black races and genetics. Recently many have been performed to assess the relationship between the higher eosinophilia and allergy levels with the incidence, progress, and severity of the cardiovascular diseases but the exact correlation between these two still remains to be understood. The current study was designed to measure the levels of allergy and immune system performance amongst patients with cardiovascular diseases in Sirjan medicals centers.Methods: This case-control study was carried out employing ۴۲ cardiovascular patients randomly selected among those admitted to the medical centers of Sirjan University of Medical Sciences in ۲۰۱۷-۲۰۱۸ as the case and ۵۲ healthy individuals without any history of allergy and parasitic infections as the control group. A questionnaire including some questions such as age, sex, smokingstatus, Familiar inheritance, etc. was completed by each participant after written consent was taken. ۷ ml blood was taken from each participant for the CBC measurements and sera were extracted from the rest for IgE using ELISA.Results: There was a significant relationship for the variables such as the family history of cardiovascular disease (P<۰.۰۱), diabetes (P<۰.۰۲), hyperlipidemia (P<۰.۰۰۱), high blood pressure (P<۰.۰۰۱) and physical activity (P<۰.۰۰۱) between the case and the control groups. The mean IgE titer in the case group was ۸۵.۳ and ۹۲.۴۴ in the control group. The mean eosinophilia level in peripheral blood was ۳.۶۵ in the case and ۱.۷۳ in the control group. The differences between the IgE and eosinophilia levels in the case and the control groups were statistically significant (P<۰.۰۰۱).Conclusion: It can be concluded that the higher amounts of IgE Antibody and the eosinophilia with genetic factors can be considered in incidence, severity and the progress of different types of cardiovascular diseases so that the cardiologists can rely on the role of these variables in the diagnosis of cardiovascular diseases.

Authors

Alireza Rafati

Department of Clinical Laboratory Sciences, Sirjan School of Medical Sciences, Sirjan, IRAN

Zahra Ahmadi Pour

Department of Clinical Laboratory Sciences, Sirjan School of Medical Sciences, Sirjan, IRAN

Nastaran Edalat Pour

Department of Public Health, Sirjan School of Medical Sciences, Sirjan, IRAN

Morteza Sedoghi

Department of Clinical Laboratory Sciences, Sirjan School of Medical Sciences, Sirjan, IRAN