Association of rs۷۹۷۵۲۳۲ SNP with the risk of multiple sclerosis
Publish place: the fourth International and 16th National Genetics Congress
Publish Year: 1399
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
CIGS16_308
تاریخ نمایه سازی: 14 اردیبهشت 1400
Abstract:
Background and Aim: Background: Multiple Sclerosis (MS) is an autoimmune disease with various unknown aspects of etiology. Aim: This study was aimed to evaluate the association of rs۷۹۷۵۲۳۲ variation of the VDR gene and MS susceptibility.Methods: The current experimental study was done on ۱۰۱ patients with MS and ۱۰۱ healthy controls. After the blood sample collection, the genomic DNA was isolated by a commercial kit. The samples were genotyped by PCRRFLP method.Results: Statistical analysis revealed that AC genotype had a significant association with the risk of MS (OR=۱.۹۷۹۸, ۹۵% CI=۱.۰۶۷۵ to ۳.۶۷۱۹, p=۰.۰۳۰۲). Besides, carriers of C allele were at high risk for MS (OR=۱.۹۷۹۸, ۹۵% CI=۱.۱۱۷۹ to ۳.۵۰۶۱, p=۰.۰۱۹۲). The allelic analysis also showed that the C allele had a significant association with an elevated risk of MS (OR=۱.۵۶۷۳, ۹۵% CI=۱.۰۴۵۱ to ۲.۳۵۰۴, p=۰.۰۲۹۸).Conclusion: According to our findings, rs۷۹۷۵۲۳۲ variation can be a risk factor for MS. However, further studies with a larger sample size are necessary to obtain more accurate results.
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Authors
Nader Mazrouei-Arani
Anatomical Sciences Research Center, Kashan University of Medical Sciences, Kashan, Iran
Shirin Tavvabi
Anatomical Sciences Research Center, Kashan University of Medical Sciences, Kashan, Iran