Effect of hsa-miR-۷۶۵ on differentiation of stem cell by targeting of BAX, BAK۱ and BOK genes

Background and Aim: Apoptosis is a way for loss of unwanted cells during development, homeostasis and integrity of tissues which is a caspase dependent process started through extrinsic and intrinsic or mitochondrial pathways. During a bioinformatic survey, important targeting miRs in both pathways have been identified.Methods: In this study, the Effect of hsa-miR-۷۶۵ on differentiation of stem cell by targeting of BAX, BAK۱ and BOK genes have been investigated.Results: According to the results, it may be concluded that miR۷۶۵ is one of the key players in the upstream of mitochondrial pathway of apoptosis.Conclusion: In fact, this regulator can affect the fate of stem cells through regulating of main involving protein in permeabilization of outer membrane of mitochondria like Bak۱, Bok and Bax thereby rendering cell towards cardiomyocytes or apoptosis.

Keywords:

Apoptosis , differentiation , miR ۷۶۵ , stem cell