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Title

Insight into the binding of Nano-Berberine with alphalactalbumin: spectroscopic and molecular docking approaches

Year: 1399
COI: NANOB03_013
Language: EnglishView: 34
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Authors

Kimia kaffashi - Department of Biology, Faculty of Sciences, Mashhad Branch, Islamic Azad University, Mashhad, Iran
Mohammad hossein shabahang - Department of Biology, Faculty of Sciences, Mashhad Branch, Islamic Azad University, Mashhad, Iran
Jamshidkhan Chamani - Department of Biology, Faculty of Sciences, Mashhad Branch, Islamic Azad University, Mashhad, Iran

Abstract:

Alpha-Lactalbumin is the main whey protein in human milk. It has a key function in the synthesis of lactose from glucose and galactose in the mammary gland although this compound has also other beneficial effects on the infant health due to the high proportion of essential amino acids (tryptophan and cysteine)[۱]. Berberine, a bioactive alkaloid isolated from several herbal substances, possesses multiple pharmacological effects, including antimicrobial, antidiabetic. Berberine has been reported to inhibit cell proliferation and to be cytotoxic towards cancer cells anticancer activities[۲, ۳]. In this study we reveal the Nano-Berberine effects upon interaction with Alpha-lactalbumin by using the biophysical methods and molecular docking.The secondary structure of alpha-lactalbumin has been changed upon interaction with Nanoberrberine that showed electrostatic forces induced. Stern-Volmer plots revealed the binding affinity of Nano-berberine to alpha-lactalbumin from the viewpoint of interaction behavior type.

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This Paper COI Code is NANOB03_013. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1196588/

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kaffashi, Kimia and shabahang, Mohammad hossein and Chamani, Jamshidkhan,1399,Insight into the binding of Nano-Berberine with alphalactalbumin: spectroscopic and molecular docking approaches,Third International Conference on Interdisciplinary Studies in Nanotechnology,Tehran,https://civilica.com/doc/1196588

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Type of center: Azad University
Paper count: 9,324
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