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Title

Synthesis and characterization of solid lipid nanoparticles loaded with Fomes fomentarius polysaccharides as a potential in diabetes treatment

Year: 1399
COI: NANOB03_014
Language: EnglishView: 52
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Authors

Mohamad keshavarz rezaei - Department of Life Sciences Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran
Zahra Beagom Mokhtari Hosseini - Chemical Engineering Group, Faculty of Petroleum and Petrochemical Engineering, Hakim Sabzevari University, Sabzevar, Iran
Ashrafalsadat Hatamian Zaremi - Department of Life Sciences Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran
Bahman Ebrahimi Hosseinzadeh - Department of Life Sciences Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran
Hale Alvandi - Department of Life Sciences Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran
Meisam Rooki - Department of Life Sciences Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran

Abstract:

Common diabetes medications have many side effects. Ethanol extract from a culture medium of Fomes fomentarius has shown anti-inflammatory and hypoglycemic effects due to polysaccharides such as betaglucans that increase PI۳K/Akt activity. However, low solubility and chemical or enzymatic degradation lead to reduce polysaccharides efficacy. Controlled delivery of these polysaccharides improves its therapeutic effect and bioavailability. Among delivery systems, solid lipid nanoparticles (SLNs) have shown many advantages, such as biocompatibility and ease of manufacturing processes. In this study, solid lipid nanoparticles containing polysaccharides were prepared by the microemulsion method. The mean particle size and the zeta potential of SLNs were ۲۰۳.۱ nm and -۲۵.۵ mV, respectively. The drug entrapment efficiency (EE) and loadingefficiency (LE) were determined using UV-visible spectroscopy were reached up to ۹۳.۶ % and ۹.۲۷%, respectively. In vitro release studies showed a sustained release of polysaccharides from SLNs. FTIR study of polysaccharide loaded SLN showed the main peaks of polysaccharide and lipid, indicating no chemical interaction between drug and lipid. TGA analysis showed appropriate thermal stability of SLNs and good incorporation of polysaccharides in SLNs.

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keshavarz rezaei, Mohamad and Mokhtari Hosseini, Zahra Beagom and Hatamian Zaremi, Ashrafalsadat and Ebrahimi Hosseinzadeh, Bahman and Alvandi, Hale and Rooki, Meisam,1399,Synthesis and characterization of solid lipid nanoparticles loaded with Fomes fomentarius polysaccharides as a potential in diabetes treatment,Third International Conference on Interdisciplinary Studies in Nanotechnology,Tehran,https://civilica.com/doc/1196589

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Type of center: دانشگاه دولتی
Paper count: 63,994
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