Antenatal Corticosteroids and Respiratory Distresses Outcome in Preterm Neonates

Background: The value of antenatal corticosteroid regimen in lessening respiratory distress risk in preterm neonates has been well known, and accordingly, antenatal corticosteroid therapy was recommended for any pregnant woman likely to deliver between ۲۴ and ۳۴ weeks of gestation. Therefore, this study aimed to assess the association between the administration of antenatal corticosteroids within the ideal interval of one week before birth and the outcomes of preterm neonates. Methods: This prospective cohort study included ۸۰ preterm neonates admitted to the neonatal intensive care unit with gestational age from ۳۲ to ۳۷ complete weeks at Suez Canal University Hospitals, Ismailia, Egypt. The newborns were then divided into groups A (did not receive antenatal corticosteroids; n=۴۰) and B (received antenatal corticosteroids; n=۴۰). Results: Severe respiratory distress syndrome was significantly less frequent in group B  (P<۰.۰۵) with lower levels of need for oxygen supplementation (P<۰.۰۵). Conclusion: Neonates who received antenatal corticosteroids developed less severe respiratory distress, compared to neonates who did not receive this medication. The results favored the use of antenatal corticosteroids to prevent respiratory distress when administrated within the ideal interval of one week before birth.    

Keywords:

antenatal , Corticosteroids , Preterm , Respiratory Distress Syndrome (RDS)