Quantitative analysis of p۵۳ substitution mutation and breast cancer; An informative study in Iranian population

Genetic factors including genetic variations in important genes may influence breast cancer susceptibility. One of important gene variations is p۵۳ codon ۷۲ which might impact risk of breast cancer. There are three case-control genetic association studies regard to the relation of this polymorphism with breast cancer risk in Iranian females, but the outcomes are indecisive. So, a meta-analysis was made in Iranian population in this regard. The eligible studies were found using search in appropriate databases. So, the extracted information from comprised studies was examined by Open Meta analyst program. The analyzed data displayed that there is no substantial correlation of p۵۳ codon ۷۲ substitution with risk of breast cancer in CC vs. GG (OR= ۰.۸۴۴, ۹۵%CI= ۰.۲۴۴-۲.۹۱۶, p= ۰.۷۸۹) and GC vs. GG (OR= ۱.۲۱۵, ۹۵%CI= ۰.۸۸۰-۱.۶۷۶, p= ۰.۲۳۷) models in Iran. Regarding to the outcomes, the aforementioned polymorphism is not a molecular risk factor for breast cancer in Iranian population.

Keywords:

breast cancer , p۵۳ gene , Genetic polymorphism , Meta-analysis