Rezvan Asgari - Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

Estrogen hormone is involved in the process of reproduction by banding to estrogen receptors (ERs). The findings of previous studies showed the association of a common variant, PvuII T/C (rs ۲۲۳۴۶۹۳), in ESR۱ gene with different aspects of reproductive process in women. Thus, the present review focused on effect of this genetic variant on reproductive process in females. The results demonstrated that the variant of ESR۱ PvuII T/C (rs ۲۲۳۴۶۹۳) could be associated with numbers of collected oocyte, maturation and embryo quality, spontaneous abortions, pregnancy rate following in vitro manipulations, preeclampsia, predisposition to endometriosis and infertility. In conclusion, the present study suggested that ESR۱ PvuII T/C (rs ۲۲۳۴۶۹۳) variant might play an important role in potential of females fertility given to the various ethnic backgrounds. Nonetheless, further studies are required in order to determine the more exact role of this variant in the infertility of women.

Estrogen Receptor, ESR۱ PvuII T/C Variant, Reproduction, Infertility