Joao Hernando Alves - Universidade Federal do Ceara, Av. Comandante Maurocelio Rocha Ponte, ۱۰۰-Derby ۶۲.۰۴۲-۲۸۰-Sobral-CE, Brazil
Francisco Placido Arcanjo - Universidade Federal do Ceara, Av. Comandante Maurocelio Rocha Ponte, ۱۰۰-Derby ۶۲.۰۴۲-۲۸۰-Sobral-CE, Brazi
Mikkael dos Santos - Centro Universitario INTA, Rua Coronel Antonio Rodrigues Magalhaes, ۷۰۰-Dom Expedito ۶۲.۰۱۱-۲۳۰-Sobral-CE, Brazi
Carolina de Carvalho - Universidade Federal do Ceara, Av. Comandante Maurocelio Rocha Ponte, ۱۰۰-Derby ۶۲.۰۴۲-۲۸۰-Sobral-CE, Brazi
Cecilia Arcanjo - Universidade Federal do Ceara, Av. Comandante Maurocelio Rocha Ponte, ۱۰۰-Derby ۶۲.۰۴۲-۲۸۰-Sobral-CE, Brazi

Background: According to estimates by the World Health Organization and the CDC’s Autism and Developmental Disabilities Monitoring (ADDM) Network, the prevalence of Autistic Spectrum Disorder (ASD) has increased significantly in recent decades, reaching today approximately ۱ in every ۶۸ children. Objective: The aim of this study was to identify the state of knowledge regarding markers, predictors, and early diagnosis of ASD (۰-۲۳ months of age). Method: A search was conducted for articles published in the PubMed Central: PMC scientific literature database, using the “autism spectrum disorder” and “early diagnosis” search algorithms. The following inclusion criteria were observed: articles describing predictors and early markers, and methods of diagnosis of ASD in infants. Results: A total of ۶۵ documents were considered eligible and submitted to the full text review, of which ۴۲ met the inclusion criteria: ۱۶ with predictors, ۹ with early markers and ۱۶ with diagnostic tests for ASD. Conclusion: There is still a need to strengthen evidence for the clinical practice of ASD diagnosis by two years of age. The findings of this study regarding predictors, early markers and diagnostic tests are intended to facilitate the detection and early intervention in these patients by health professionals.

Autistic Disorder, Autism spectrum disorder, Early Diagnosis, Infant Behavior, review