Mina Bonyadi
Bahram Abedi

Background: Pomegranate supplement is one of the herbal supplements with healing properties. The purpose of this study was to investigate the effect of ۸ weeks of aerobic training and pomegranate supplementation on lipid peroxidation and some adhesion molecules in obese women.   Methods: In this randomised double-blind clinical trial, forty women with BMI greater than ۳۰ kg/m۲ were randomly assigned into four groups of aerobic training, pomegranate, aerobic training + pomegranate, and placebo. Interventions were performed for ۸ weeks. The exercise program included running on a treadmill with ۶۵% of maximum heart rate for ۱۶ minutes in the first week, which peaked at ۳۰ minutes and ۸۰% of the maximum heart rate in the eighth week. The groups received either a ۲۰۰ mg supplement or a placebo daily for two months. Blood samples were collected from all subjects ۲۴ hours before and ۴۸ hours after the intervention to measure the variables. One-way ANOVA and paired t-test were used to compare the changes of variables in the four groups of study and at two blood sampling times (pre and post-test).   Results: The results showed that MDA, ICAM-۱ and VCAM-۱ significantly decreased in three intervention groups (training+pomegranates, pomegranates, and training) (p <۰.۰۵). This decrease in the pomegranate+training group was significantly higher than the other two (pomegranates, and training) groups (p <۰.۰۵).   Conclusion: It seems that eight weeks of aerobic training along with pomegranate supplementation may have a better effect on reducing inflammation and oxidative stress in preventing obesity-related diseases in obese women.

aerobic training, Pomegranate, oxidative stress, Adhesion Molecules