Molecular Characterization of Multidrug-resistant Bacteria Isolated From Patients With Pneumonia at Two Hospitals in North-West Nigeria

Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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JR_INJER-8-1_005

تاریخ نمایه سازی: 10 خرداد 1400

Abstract:

  Background and aims: The spread of antimicrobial resistance (AMR) is a serious public health threat complicating treatment and resulting in prolonged hospitalization. The prevalence of AMR threat is not well defined due to the dearth of appropriate surveillance systems. This study sought to assess the prevalence of AMR among bacterial isolates from sputum specimens obtained from patients with pneumonia presenting at two secondary healthcare facilities in Zaria from June ۱ to August ۳۱, ۲۰۱۸.   Methods: Standard methodology was followed in processing sputum samples that met the acceptance criteria. The antibiotic susceptibility patterns of bacterial pathogens cultured from sputum specimens obtained from June ۱ to August ۳۱, ۲۰۱۸) were evaluated using the recommendation of the Clinical and Laboratory Standards Institute. Finally, data were analyzed using descriptive statistics.   Results: Acinetobacter spp. were the predominant pathogens accounting for ۳۲% of recovered isolates, followed by Staphylococcus spp. (۱۸%) and Klebsiella spp. (۱۷%), respectively. AMR was found in ۹۱% of the isolates. Most isolates were resistant to erythromycin (ERY) (۸۰%) and amoxicillin (۸۳.۳%). Eventually, the multiple antibiotic resistance index ≥۰.۳ was observed in ۷۶% of the isolates.   Conclusion: Based on the findings, AMR rates were observed to be high, and may display a serious therapeutic challenge to the management of community-acquired pneumonia. Concerted efforts are needed to combat the worrisome AMR trends revealed in this study.

Authors

Paul Oyegoke

Department of Pharmaceutical Microbiology, Ahmadu Bello University, Zaria, Nigeria

Busayo Olayinka

Department of Pharmaceutical Microbiology, Ahmadu Bello University, Zaria, Nigeria

Joseph Ehinmidu

Department of Pharmaceutical Microbiology, Ahmadu Bello University, Zaria, Nigeria

Babajide Tytler

Department of Pharmaceutics and Industrial Pharmacy, Ahmadu Bello University, Zaria, Nigeria