Mansour Bahardoust - Colorectal Research Center, Iran University of Medical Science, Tehran, Iran
Marjan Mokhtare - Colorectal Research Center, Iran University of Medical Science, Tehran, Iran
Arash Sarveazad - Colorectal Research Center, Iran University of Medical Science, Tehran, Iran
Shahdieh Karimi - Internal Medicine Department, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
Atefeh Talebi - Colorectal Research Center, Iran University of Medical Science, Tehran, Iran
Arezoo Chaharmahali - Internal Medicine Department, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
Shahram Agah - Colorectal Research Center, Iran University of Medical Science, Tehran, Iran

Background and aims: Hepatitis B virus (HBV) is one of the important public health diseases in Iran.Therefore, to control the prevalence of the disease, knowledge is required regarding the risk factor ofHBV. Accordingly, the aim of this study was to determine the risk factors of HB transmission.Methods: A retrospective case-control study was conducted on the possible risk factors of HBVtransmission. To this end, a total of ۱۷۱ patients with HBV infection and ۱۷۱ controls from Rasoul-e-Akram hospital were investigated during ۲۰۱۵-۲۰۱۸. All subjects were directly evaluated using a faceto-face questionnaire about demographic aspects. Finally, HBV infection and its risk factors among thesubjects were detected using hepatitis B surface antigen test.Results: Overall, ۱۷۱ HBV patients including ۷۷ (۴۲%) males and ۹۳ (۵۸%) females were evaluated.The mean age of the participants was ۴۰ ± ۱۳ years. Univariate logistic analysis showed that HBVinfection in these cases was associated with addiction injection (odds ratio [OR] = ۴.۰۸, CI:۱.۳-۹.۵۷), family history (OR = ۴.۵۲, CI: ۱.۲۷-۱۰.۷), and having a history of blood transfusion (OR =۳.۱۶, CI: ۱.۵۲-۵.۳۷). There were no significant relationships between the liver function tests, alcoholconsumption, the history of dental visits, and HBV participants. In addition, the logistic-regressionmodel proved that patients with a history of HBV-infected parents (At least one of them) and addictioninjection were severely subject to HB infection. In other words, there was a significant associationbetween a history of HBV-infected parents and addiction injection and HB infection.Conclusion: In general, HBV infection was strongly related to having a family member infected withhepatitis B, suffering from addiction injection, and having blood injection.

Epidemiology, Hepatitis B virus, Risk Factors, Iran