The effects of Urtica dioica extract on lipid profile, insulin resistance index and liver histology in polycystic ovary syndrome-induced Wistar rats
Publish place: Future Natural Products، Vol: 1، Issue: 2
Publish Year: 1394
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JHPH-1-2_005
تاریخ نمایه سازی: 12 خرداد 1400
Abstract:
Background and aims: Urtica dioica as a medicinal herb due to its anti-inflammatory, antioxidant and hypoglycemic effects, improve type ۲ diabetes and decrease inflammation, fibrosis and necrosis as the signs of Nonalcoholic steatohepatitis. Polycystic Ovary Syndrome (PCOS) as the most important factor of infertility has an overlap of ۳۰ % to ۶۰% with liver disorders. Hence, the Urtica dioica moderator effect on liver function in PCOS rats was examined. Methods: In this experimental study ۱۴۴ adult Wistar rats were divided into control, PCOS and nettle-treated groups. The group PCOS was injected subcutaneously ۲ mg estradiol valerate, after ۶۰ days and confirmed polycystic, the experimental group was injected intraperitoneally the Urtica dioica extract doses (۱۵۰,۲۵۰, ۴۵۰ mg/kg BW). After ۲۱ days, rats were anesthetized by chloroform; blood samples and livers were collected for histological and serological evaluation. Data were analyzed using instat۳ via ANOVA one-way and p
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Authors
Samad Zare
Biological Science Dept., Urmia University, Urmia, I.R. Iran
Mohammad Nabiuni
Cell and Molecular Biology Dept., Kharazmi University, Tehran, I.R. Iran
Akram Tayanloo
Student, Animal Biology Dept., Urmia University, Urmia, I.R. Iran
Serwa Hoseini
Student, Animal Biology, Kharazmi University, Tehran, I.R. Ira
Latifeh Karimzadeh-Bardei
Laboratories’ Animal Center & Cellular And Molecular Research Laboratory, Kharazmi University, Tehran, I.R. Iran
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