Lower Serum Irisin Levels Are Associated with Increased Osteoporosis and Oxidative Stress in Postmenopausal

Background: Irisin as an exercise-induced myokine was proposed to improve bone health. This study investigated the role of serum irisin (s-irisin) in patients with osteoporosis (OP) through correlating to most biological bone markers and oxidative stress. Methods: A cross-sectional study recruited an eligible ۱۷۵ postmenopausal women at Al-Hussien Teaching Hospital, Iraq. They were scanned by DEXA and stratified into two groups based on T-score; the first ۹۵ patients as control group (GI) with −۱ ≤ T-score and the second ۸۰ patients as cases group (GII) with T-score ≤ −۲.۵. Demographic criteria were age, bone mineral density (BMD, g/cm۲ ) and T-score. Serum irisin, total serum calcium (s-calcium), serum inorganic phosphate (s-phosphate), serum alkaline phosphatase (s-ALP), serum ۲۵ [OH] vitamin D, the serum parathyroid hormone (s-PTH), serum Carboxy terminal collagen crosslinks (CTx), serum procollagen type I C-termidnal peptide (s-PICP), serum malondialdehyde (s-MDA) and serum superoxide dismutase (s-SOD) were collected from blood samples. Results: Serum irisin were ۳۱.۸۴ ± ۲.۶۵ vs. ۲۰.۸۸ ± ۲.۷۱ ng/mL for control and trial groups, respectively. Lower levels of BMD, T-score, ۲۵ [OH] vitamin D, and s-irisin along with a higher serum levels of PTH, CTx, PICP, MDA and SOD were observed in patients with osteoporosis. All parameters were statistically meaningful upon correlation (p< ۰.۰۰۰۱), except age and s-calcium (p= ۰.۰۰۸۸ and p= ۰.۱۸۷, respectively). Conclusions: The results showed that, a significantly lower serum irisin levels among osteoporosis women, was intimately correlated to most bone turnover markers and it can be considered as encouraging results for clinical application in prediction and treatment of osteoporosis

Keywords:

Bone turnover markers , DEXA scan , Irisin , T-score , BMD , osteoporosis , post-menopause.