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Title

Rheumatoid arthritis is associated with KIR۲DS۴-full among the KIR genes in Lur Population of Iran

Year: 1400
COI: JR_RBMB-10-1_010
Language: EnglishView: 118
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Authors

Bijan Ansari-Moghaddam - Department of Immunology, Lorestan University of Medical Sciences, Khorramabad, Iran.
Ali Asghar Kiani - Department of Immunology, Lorestan University of Medical Sciences, Khorramabad, Iran.
Ali Sheikhian - Department of Immunology, Lorestan University of Medical Sciences, Khorramabad, Iran.
Mehdi Birjandi - Department of Epidemiology and Biostatistics, Lorestan University of Medical Sciences, Khorramabad, Iran.
Seyyed Amir Yasin Ahmadi - Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.
Nazanin Mousavi - Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.
Hamzeh Ali Torang - Department of Internal Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
Farhad Shahsavar - Department of Immunology, Lorestan University of Medical Sciences, Khorramabad, Iran.

Abstract:

Background: The pathophysiology underlying the progression and development of autoimmune conditions, such as Rheumatoid Arthritis (RA), is a result of dysregulations of the immune system. Research has explored the genetic alterations present in RA; however, limited studies have examined the role of Killer cell Immunoglobulin-like Receptors (KIR) and Human Leukocyte Antigen (HLA) molecules in RA. Therefore, the aim of this study was to examine KIR genes, their HLA ligands, and KIR-HLA compounds in patients with RA. Methods: In this case-control study, a total of ۵۰ patients with RA and ۱۰۰ healthy individuals were enrolled. DNA samples were evaluated using PCR with sequence specific Primers (PCR-SSP). Odds ratio (OR) with a ۹۵% confidence interval (CI) were reported. Results: Among the KIR genes examined, KIR۲DLA (p= ۰.۰۲۵۵, OR= ۰.۳۸۹, ۹۵% CI= ۰.۲۱۰-۰.۷۲۲) and KIR۲DS۴-full (p< ۰.۰۰۰۱, OR= ۶.۱۶۳, ۹۵% CI= ۳.۱۷۴-۱۱.۹۶۸) were observed to have a statistically significant correlation with disease susceptibility to RA. As an inhibitory gene, KIR۲DLA was observed to have a protective effect against RA while KIR۲DS۴-full as an activating gene, was found to increase risk for RA. No significant associations were found between any of the other KIR genotypes, HLA ligands, or KIR-HLA compounds examined in this study to RA susceptibility. Conclusions: In this study of RA in the Lur population of Iran, KIR۲DS۴-full was observed to increase susceptibility to RA, while KIR۲DL۵A was found to act as a protecting factor based on both the cross Table and regression analyses. Further research should focus on repeating this study in additional populations.

Keywords:

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This Paper COI Code is JR_RBMB-10-1_010. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1225394/

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Ansari-Moghaddam, Bijan and Kiani, Ali Asghar and Sheikhian, Ali and Birjandi, Mehdi and Ahmadi, Seyyed Amir Yasin and Mousavi, Nazanin and Torang, Hamzeh Ali and Shahsavar, Farhad,1400,Rheumatoid arthritis is associated with KIR۲DS۴-full among the KIR genes in Lur Population of Iran,https://civilica.com/doc/1225394

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