Uncoupling Protein ۲ Expression Modulates Obesity in Chronic Kidney Disease Patients

Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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JR_RBMB-10-1_013

تاریخ نمایه سازی: 17 خرداد 1400

Abstract:

Background: Obesity is a multifactorial metabolic disease resulting from behavioral and genetic factors. Obesity is linked to diabetes mellitus and hypertension, which are considered as major risk factors for chronic kidney disease (CKD); moreover, it has a direct effect on developing CKD and end stage renal disease (ESRD). Here was aimed to examine the association between uncoupling protein ۲ (UCP۲) gene expression and obesity in CKD patients. Methods: UCP۲ gene expression was analyzed by real time polymerase chain reaction (RT-PCR) in ۹۳ participants divided into three groups. The groups included ۳۱ non-obese CKD patients, ۳۱ obese CKD patients, and ۳۱ healthy, age-matched, unrelated volunteers as a control group. Results: UCP۲ gene expression was significantly relevant when comparing the non-obese CKD and obese CKD groups to the control group (p< ۰.۰۰۱). No significant association was found when the groups were compared by gender; Chi-square (X۲) was ۲.۳۸ and p= ۰.۳۰۴. A significant negative correlation was found between UCP۲ gene expression and BMI in CKD (p< ۰.۰۵). Conclusions: These results indicate that UCP۲ gene expression plays a significant role as a risk factor for obesity in CKD patients.

Keywords:

Chronic kidney disease (CKD) , obesity , Uncoupling protein ۲ (UCP۲) gene expression , Real-Time polymerase chain reaction (RT-PCR)

Authors

Salma Ahmed Shawky

Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Osama Gaber

Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Ezzat Mostafa

Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Walaa Mohamed Sarhan

Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

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