Abhilasha Singh Panwar - R, MBBS, Pediatrics Resident, Deptt. of Paediatrics, Jawaharlal Nehru Medical College, Sawangi Meghe, Wardha, Maharashtra : ۴۴۲۰۰۴, India.
Amar Taksande - MD, FIAE, Fellow in Ped Card., Professor, Deptt. of Paediatrics, Jawaharlal Nehru Medical College, Sawangi Meghe, Wardha, Maharashtra : ۴۴۲۰۰۴, India.
Syed Athhar Saqqaf - MBBS, Pediatrics Resident, Deptt. of Paediatrics, Jawaharlal Nehru Medical College, Sawangi Meghe, Wardha, Maharashtra : ۴۴۲۰۰۴, India.
Rewat Meshram - MD, Associate Professor, Deptt of Paediatrics, Jawaharlal Nehru Medical College, Sawangi Meghe, Wardha, Maharashtra: ۴۴۲۰۰۴, India.

Holt-Oram syndrome (HOS) is an autosomal dominant disorder, a mutation in TBX۵ gene located on chromosome ۱۲ (۱۲q۲۴.۱) involving the upper limb and the heart, causing malformations like atrial septal defect. Herein, we report a rare case of HOS with atrial septal defect and ventricular septal defect with severe pulmonary arterial hypertension in a three-year-old child.

Child, Heart-hand syndrome, Holt-Oram syndrome, Ventricular Septal Defect