Electrochemiluminesence Epidemiologic Detection of Toxoplasma gondii Infection in Pregnant Women With Direct and Indirect Diagnostic Techniques (ELISA Avidity Plus Biochemical Assay)

Publish Year: 1397
نوع سند: مقاله ژورنالی
زبان: English
View: 158

This Paper With 6 Page And PDF Format Ready To Download

  • Certificate
  • من نویسنده این مقاله هستم

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این Paper:

شناسه ملی سند علمی:

JR_INJER-5-1_006

تاریخ نمایه سازی: 19 خرداد 1400

Abstract:

Background and aims: Toxoplasmosis is a very common disease in the world. Two types of acquiredtoxoplasmosis have been detected. In the chronic toxoplasmosis, the abnormality of tissue functionis little but, in acute toxoplasmosis, function of RES system becomes interrupted. The assessment oftoxoplasma antibody with tissue enzymes in this stage is very important. Furthermore, serum ferritinin some conditions became high in acute phase of infectious disease.Methods: This study was based on comparative abundance study. Materials consisted of ۹۸۰ serumand amniotic fluid samples collected from human blood with high level of IgG antibody againstToxoplasma gondii in Rajaie center, Tehran, Iran. The standard test was ELISA assay to detect theseantibodies and the main test was measurement of liver transaminases (SGOT, SGPT) bilirubin andferritin to evaluate acute toxoplasmosis. Data analysis was done by SPSS version ۱۸.۰. This study wasdone during March to June, ۲۰۱۷.Results: Results showed that in some patients with high level of IgG AVIDITY antibody against T. gondiithe level of liver transaminases, serum bilirubin and ferritin became increased. For example in ۱۲۰patients with acute toxoplasmosis the mean serum levels of SGOT were ۱۰۸ IU/L and in ۸۰ patientsthe mean serum bilirubin were about ۵ mg/dL.Conclusion: In acute congenital toxoplasmosis, the evaluation of IgG AVIDITY was first step and thenthe measurement of biochemical factors such as serum transaminases, serum Bilirubin and serumFerritin were important.

Authors

Ehsan Shariat Bahadory

Department of Medical Parasitology, Faculty of Medical Sciences, Tarbiat Modaress University, Tehran, Iran

Ali dalir Ghaffari

Department of Medical Parasitology, Faculty of Medical Sciences, Tarbiat Modaress University, Tehran, Iran

Somayyeh Namroodi

Assistant professor, Department of Environmental sciences, Faculty of Fisheries and Environmental Sciences, University of Agricultural Sciences & Natural Resources, Gorgan, Iran

Seyyedeh Somayyeh Mosavipour

Department of Nursing, Faculty of Medical Sciences, Tehran Medical Sciences University, Tehran, Iran

Javid Sadraei

Department of Medical Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran