Liver cancer is the sixth most common cancer worldwide and the third leading cause of death from cancer. Liver cancer is more prevalent in countries in East Asia, Southeast Asia and the western Central Africa.۱ Liver cancer rates in North America and Western Europe, less than ۱۰ cases per hundred thousand people in Asia and Africa between ۵۰-۱۵۰ cases per hundred thousand people.۲ The incidence of cancer in many countries such as the United States and Central America and Europe is on the rise because it is caused by the epidemic of obesity and increasing cases of HCV infection due to intravenous drug. In contrast, in high-risk areas, decreasing trend has been observed Because of widespread vaccination against HBV infection in adults and children.۱ The aim of this study was to estimate the level and trend of mortality from
liver cancer in Iranian population during ۲۰۰۶-۲۰۱۰ .The overall view of the process as far as mortality due to these cancers in
Iran is provided. In this study, Data related to the number of deaths caused by Liver cancer during ۲۰۰۶ to ۲۰۱۰ in ۲۹ provinces by the Network Management Centre, Department of Information Management and Technology and Applied Research of the Ministry of health and Medical Education from various sources including government organizations, cemeteries, hospitals, homes and the Ministry of Health and Medical Education were collected.۳ The results of calculation of mortality rates per hundred thousand people showed that the rate of death from
liver cancer was ۴.۷۸ in ۲۰۰۶ to ۵.۳۷ in ۲۰۱۰. In Table ۱, the mortality rate in all the years under the study suggests that
liver cancer in men is more than in women. The results show that the mortality of
liver cancer has been increased; this trend is consistent with previous studies.۴ Deaths from cancer in the UK have increased by ۲.۶ per hundred thousand people.۵ Rates of
liver cancer mortality in the age groups under the study show that it increases with the increasing age of the cancer death rate and most deaths have been reported in patients aged over than ۷۰ years. Based on the results of the present study, death from
liver cancer in men has more increases with age than in women. Table ۱:
Mortality from Liver cancer per hundred thousand people in the study group sex Year of Study Mortality per hundred thousand Crude mortality rate Sex ratio (M/F) Woman Man Total Woman Man Total ۲۰۰۶ ۳.۸۱ ۵.۷۲ ۴.۷۸ ۱۰۷۲ ۱۶۵۹ ۲۷۳۱ ۱.۵۴ ۲۰۰۷ ۴.۲۱ ۵.۸۵ ۵.۰۴ ۱۱۰۳ ۱۵۷۳ ۲۶۷۷ ۱.۴۲ ۲۰۰۸ ۴.۴۱ ۵.۸۴ ۵.۱۳ ۱۱۷۰ ۱۵۸۷ ۲۷۵۷ ۱.۳۵ ۲۰۰۹ ۴.۰۹ ۶.۰۶ ۵.۰۹ ۱۱۰۰ ۱۶۶۸ ۲۷۶۹ ۱.۵۱ ۲۰۱۰ ۴.۵۱ ۶.۱۲ ۵.۳۷ ۱۲۵۸ ۱۷۰۶ ۲۹۶۴ ۱.۳۵ Total ۵۷۰۳ ۸۱۹۳ ۱۳۸۹۸ ۱.۴۳ Because both hepatitis B and hepatitis C are the major causes of liver cancer, treatment can reduce the risk of cancer, although this effect is not clear. It is estimated that approximately ۱.۵ million people in the country are infected with hepatitis B of which more than ۱۵% to ۴۰% are at risk of developing cirrhosis or liver cancer.۶ The mass vaccination is a safe and easy way to control hepatitis B in the population, which can reduce infection rates by up to ۹۵%. The universal vaccination against hepatitis B in
Iran from ۱۹۹۳ to ۲۰۰۶ and applying it to more than ۹۴% is reached.۷ It is expected that the effect of reducing the burden of developing
liver cancer occurs in the next decade. Since that time an attention on the course of hepatitis B and
liver cancer and the virus vaccination for infants is recommended. It is also recommended that screening be performed for people with hepatitis B to identify cases of liver cancer.