Nourolhoda Razavi - Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad. Mashhad, Iran
Amene Zendegi-Shiraz - Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad. Mashhad, Iran
Zarrin Eshaghi - Department of Chemistry, Payame Noor University, ۱۹۳۹۵-۴۶۹۷ Tehran, Iran

This study considers identification and determination of phthalates esters in cosmetic samples. The dispersive solid phase extraction was used for extraction of analytes prior to high performance liquid chromatography analysis. The solid sorbent for extraction was polyethylene glycol grafted on cupric oxide nanoparticles (PEG-g-CuO-NPs). This sorbent was first synthesized and characterized by scanning electron microscopy (SEM), Energy-dispersive X-ray(EDX) and fourier-transform infrared spectroscopy (FT-IR) then efficiently applied for extraction of analytes. The extraction conditions like amount of sorbent, kind and volume of desorption solvent, extraction and desorption time, and pH of sample solution were optimized. The validation of method carried out under optimum conditions. Linear ranges were ۰.۰۰۵-۴ µgmL-۱ with the coefficient correlation (R۲) in the range of ۰.۹۹۱۴-۰.۹۹۶۲. The limits of detection (LODs) (۳S/N) were ۰.۰۰۲۵ to ۰.۰۰۵ µgmL-۱ and acceptable repeatability’s (RSDs below ۶.۴۵%, n=۵) obtained. Application of proposed method was investigated by extraction of phthalates in shampoo and body wash for babies which satisfaction results achieved.

phthalate esters, HPLC, Baby shampoo, Body wash, polyethylene glycol grafted cupric oxide nano particles