Neda Esfandiari - Department of Nanobiotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran

Background: Viral nanoparticles are biodegradable, biocompatible, selfassembling,and highly symmetric, and can be produced in large quantities.Several plant viral nanoparticles (VNPs) have been exploited in different areas ofnanobiotechnology, especially drug delivery in cancer therapy. In this study, aflexuous plant virus called potato virus X (PVX) is presented with a uniquenanoarchitecture which can increase tumor homing and penetration. Thus, thisstudy aimed to investigate the potential of PVX for delivering Herceptin (HER) indifferent breast cancer cells and normal cells.

Breast cancer cell lines, cytotoxicity, Herceptin, plant viral nano particles, Potatovirus X (PVX)