Sanaz Zand - Department of Research, Kaviani Breast Disease Institute (KBDI), Tehran, Iran
Roghayye Jalili - Department of Surgery, Tehran University of Medical Sciences (TUMS), Tehran, Iran
Seyed Hasan Emami Razavi - Department of Surgery, Tehran University of Medical Sciences (TUMS), Tehran, Iran
Massoome Najafi - Department of Surgery, Tehran University of Medical Sciences (TUMS), Tehran, Iran- International Center for Surgical Safety (ICSS), St. Michael Hospital, University of Toronto, Canada
Ahmad Kaviani - Department of Research, Kaviani Breast Disease Institute (KBDI), Tehran, Iran- Department of Surgery, Tehran University of Medical Sciences (TUMS), Tehran, Iran

Background: Warfarin induced breast necrosis is a rare complication of oralanticoagulant therapy. Although it can be related to protein C, S, and antithrombinIII deficiency; the pathogenesis of necrosis is still unknown.Case presentation: We report a case of a ۳۸-year-old woman with extensive leftbreast necrosis after receiving warfarin for treatment of deep vein thrombosis.Simple mastectomy was performed and the wound was closed secondarily with anabdominal advancement flap. Rivaroxaban was prescribed after discontinuation ofwarfarin.Conclusion: Although breast necrosis following warfarin usage is uncommon,it should be considered in women presenting with breast symptoms after initiationof warfarin. Early diagnosis and appropriate management are essential to preventextensive loss of breast tissue.

Warfarin, breast necrosis, breast gangrene, oral anticoagulant therapy