Background: Although various Oncoplastic Breast Surgery (OBS) techniqueshave been introduced for various sizes of the breast and locations of tumors , surgeonsare still faced with serious challenges for the tumors which have developed in specialanatomic parts of the breast. A good instance of these challenges is with the tumorslocated far from the Nipple Areola Complex (NAC) especially in the upper innerquadrant. We aimed to assess the application of the newly introduced OBS technique(Cross Technique) for tumors in these locations.Methods: The data of ۹۵ patients who were suffering from breast cancer and operatedwith the Cross method were assessed in this prospective survey. Data was gatheredregarding demographic variables, the size, location, and pathologic characteristics oftumors as well as the patients' BMI, breast circumference, and cup size. The patients wererecruited to the study according to the inclusion and exclusion criteria and the studyprotocol which was approved by the research deputy surgery department in TehranUniversity of Medical Sciences. The data was then presented in a descriptive method. Results: Nighty-five patients underwent oncoplastic breast surgery using theCross method in a span of time from November ۲۰۱۵ to May ۲۰۱۸. The patients had amean age of ۴۸.۲ (ranging from ۲۵ to ۷۰ years) as well as ta wide range of breastcircumferences and cup sizes (۷۰ to ۹۵ for the breast circumferences and A to E for thecup size). Clear surgical margins were obtained in ۹۳ cases according to the permanentpathology reports. Complications were seen in ۵ patients (۲ slight hematoma and threeischemic skin flaps) all of which were managed conservatively. The most commonhistologic types of tumors were insitu and invasive ductal carcinoma (DCIS-IDC).The mean tumor size was ۲۲.۷ mm with a standard deviation of ۹.۲mm and most ofthe tumors were positive for estrogen receptor (ER)/progesterone receptor (PR). In thesurgery of axilla, an average of six lymph nodes were excised while ۲۲ patients werefound out to have axillary lymph node involvement. Conclusion: Not only is the Cross method is not only a reliable choice for tumorslocated in the upper inner quadrant (UIQ), but it can also be applied safely for the tumorsin upper outer quadrant (UOQ) and upper central part of the breast, although the bestapplication for the technique is the tumors located far from the nipple areola complex.