Using Fe۳O۴@FAp@Ni as a novel nanocatalyst for synthesis of polyfunctional indole-pyrido[۲,۳-d]pyrimidine hybrids as biologically important scaffolds

In the present research, we have developed a novel prtocol for the synthesis of indole-pyrido[۲,۳-d]pyrimidine hybrids by using Fe۳O۴@FAp@Ni as a recyclable and impactful nanocatalyst. The structure of this nanocatalyst was confirmed by EDX, XRD, Fe-SEM and FT-IR analyses. The catalytic activity of Fe۳O۴@FAp@Ni nanoparticles was examined in the three-component synthesis of polyfunctional indole-substituted pyrido[۲,۳- d]pyrimidines (۱). In this new method the products were obtained at high to excellent yields (۷۵-۹۵%) and short reaction times.

Keywords:

magnetic nanocatalyst , pyrido[۲ , ۳-d]pyrimidines , biologically scaffolds.