Omid Mirzaee - Students Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
Abdolhamid Shariat - Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Faezeh Sehatpour - Students Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
Mojtaba Neydavoodi - Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Fatemeh Roozbeh - Students Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
Seyedeh Shaghayegh Zafarmand - Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Maryam Owjfard - Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Shekoofeh Rahimi - Students Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
Anahid Safari - Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Afshin Borhani-Haghighi - Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Objective(s): This study evaluated the impact of statin on the severity and outcome of stroke among patients who had taken it prior to the stroke onset and compared to patients who had not received it before the stroke. Methods: We included ۲۶۱ consecutive patients with acute ischemic stroke who admitted in Namazee hospital affiliated to Shiraz University of Medical Sciences from ۲۰۱۸-۲۰۱۹. We recorded demographic data, vascular risk factors, history of previous statin treatment, and National Institutes of Health Stroke Scale (NIHSS) score at time of hospital admission and modified Rankin Scale (MRS) ۳ months after stroke onset. The dependent variables were initial severity of stroke as measured by National Institute of Health Scoring System (NIHSS) and good outcome defined as modified Rankin Scale (MRS) ۰ to ۱. Results: Among ۲۶۱ patients with acute ischemic stroke, ۷۶ were using statins (۵۲.۶% of users were women). Among all the subjects, ۱۷۵ (۶۷.۶%) had history of hypertension, ۷۸ (۳۰.۱%) had history of diabetes mellitus, ۸۷(۳۳.۵%) had history of hyperlipidemia, ۶۳ (۲۴.۳%) were smokers. Admission NIHSS and MRS were not statistically different in statin users and non-statin users (P= ۰.۱۲ and P= ۰.۰۸, respectively). Adjusted Odds Ratios for poor functional outcome and ۹۰-day mortality according to previous statin use were ۰.۸۷ (۹۵% CI ۰.۳۷-۲.۰۵), P= ۰.۵۴) and ۰.۷۵(۹۵% CI ۰.۳۱-۱.۸۱, P= ۰.۵۲) which were not statistically significant. Conclusion: This study showed that pre-stroke statin therapy did not affect the initial clinical severity, short-term functional outcome and ۹۰-day mortality after ischemic stroke.

Stroke, ischemic stroke, statin