Neurodevelopmental Outcome of Patients With Agenesis of Corpus Callosum

Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_CJNS-7-2_005

تاریخ نمایه سازی: 19 تیر 1400

Abstract:

Background: Agenesis of Corpus Callosum (ACC) is a type of brain dysgenesis with various clinical manifestations. Objectives: This study aimed to investigate the clinical and neurodevelopmental outcomes of patients with ACC. Materials & Methods: In this cross-sectional study, the clinical and neurodevelopmental conditions of ۶۲ patients with complete ACC referred to subspecialty clinics of pediatric neurology, Isfahan University of Medical Sciences, Isfahan, Iran, were investigated. Quantitative data were shown as Mean±SD, and qualitative data as frequency or percentage. In addition, the f Chi-square test was used to compare some data in SPSS version ۲۲. Results: In this study, ۶۲ patients, including ۲۹ boys and ۳۳ girls with a Mean±SD age of ۴.۹۹±۵.۰۷ years, were included. Among the patients examined, ۵۴.۴% were born of consanguineous marriage, ۸۲% had developmental delays, ۸۰.۴% had mental retardation, ۸۹.۱% had a speech delay, ۲۳.۷% had nutritional problems, ۴۲.۴% had facial dysmorphic features, and ۲۷.۶% had abnormalities of muscle tone. Among the associated problems stated by the patients, ۱۵.۵% of them had heart diseases, ۲۲.۴% visual disorders, ۵.۲% hearing deficit, ۲۵.۸% behavioral problems, ۵۰% seizures, and ۵۳.۳% had abnormal electroencephalogram. Interestingly, ۱۲.۹% of the patients had normal or near-normal development. Conclusion: The prevalence of developmental delays, speech and language disorders, mental retardation, facial deformities, seizures, and abnormal muscle tone were common in the patients with ACC.

Keywords:

Agenesis of corpus callosum , Epilepsy , Brain

Authors

Jafar Nasiri

Department of Pediatric Neurology, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.

Maryam Sedghi

Medical Genetics Laboratory, Alzahra University Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.

Mohammad Hossein Hemat

Department of Pediatric Neurology, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.