Zahra Goudarzy - Department of Mining and Metallurgical Engineering, Amirkabir University of Technology, Tehran, Iran
Amir Hossein Ijadi - Department of Mining and Metallurgical Engineering, Amirkabir University of Technology, Tehran, Iran
Ameneh Bakhtiari - Department of Mining and Metallurgical Engineering, Yazd University, Yazd, Iran
Sara Eskandarinezhad - Department of Mining and Metallurgical Engineering, Yazd University, Yazd, Iran
Negar Azizabadi - Department of Chemistry, Science and Research Branch, IAU, Tehran, Iran
Mohammadreza Asgari Jazi - Department of dentistry , Isfahan (khorasgan) Branch , Islamic Azad University

In this work, sol–gel derived bioactive glasses (BGs) system of ۶۰% SiO۲-(۳۶-x) CaO-۴P۲O۵-x SrO (where x = ۲, ۴, ۶ and ۸ mol%) were obtained. The bioactivity and proliferation of G۲۹۲ cells was investigated for Sr-containing BGs. X-ray diffraction analysis (XRD), Scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) were utilized to study the obtained phases, hydroxyapatite (HA) morphology, and its functional groups, respectively. The XRD and FTIR tests showed that the rate of hydroxyapatite formation on sample ۲S was higher than that of other samples. Also ۳-(۴,۵ dimethylthiazol-۲-yl)-۲,۵-diphenyltetrazolium bromide (MTT) assay was performed after one day showed that the sample containing ۶ mol% of Sr (۶S) showed higher viability. However, the sample with ۸ mol% Sr (۸S) showed a decrease in bioactivity in osteoblast G۲۹۲ cells proliferation. According to the results ۶S BG specimen with ۶ mol% SrO exhibited appropriate bioactivity and cell proliferation. This showed that the obtained BGs can be potentially used for drug delivery systems as well as dental and orthopedic applications.©۲۰۱۹ jourcc. All rights reserved.

Bioactive glass, Implant, Strontium, Drug delivery