Mahbobeh Khammar - Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Sepideh Hassanzadeh - Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Fatemeh Tara - Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Malihe Siahsar - Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Fatemeh Tahmasbi - Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Masoud Keikha - Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Kiarash Ghazvini - Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Introduction:In the present study, we evaluated the ۴-year antimicrobial resistance trends of several nosocomial pathogens during ۲۰۱۸-۲۰۲۱ in a reffereal Mashhad hospital, Mashhad, Iran. Methods:In this study, we reviewed the data of ۷۰,۲۳۴ clinical isolates were registred Infection Control Data of Ghaem Hospital, Mashhad, Iran. The antimicrobial susceptibility testing was performed using Kirby-Bauer disk diffusion method according to clinical and laboratory standard institute (CLSI) instructions to evaluate trends of antimicrobial resistance over the times. Results: There were identified (A. baumannii: n = ۱۹,۳۷۴; K. pneumonia n = ۱۷,۲۰۶; E. coli n = ۲۳,۷۷۷; S. epidermidis: n = ۹,۸۷۷). We did not find any significant difference in changes of antimicrobial trends over the time except in minor cases . However, The pattern of antimicrobial drug resistance was gradually differed except E. coli. Conclusion: our results suggested the overall antimicrobial resistance trends was remins the same level during ۲۰۱۸-۲۰۲۱. It seems that in accessibility and stop prescribing of antibiotics can lead to decreasing antibiotic resistance rate.

Staphylococcus epidermidis, Escherichia coli, Klebsiella pneumonia, Acinetobacter baumanii, Antimicrobial resistance