Improved hormonal and oxidative changes by Royal Jelly in the rat model of PCOS: An experimental study

Background: Polycystic ovarian syndrome (PCOS) is an endocrine and complex metabolic disorder, associated with anovulation, changes in sex hormone, biochemical factors, and ovarian tissue. Royal jelly (RJ) has antioxidant and anti-inflammatory properties. Objective: To examine the therapeutic effect of RJ on PCOS-related hormonal and biochemical changes in a rat model of PCOS. Materials and Methods: In this experimental study, ۴۲ female Wistar rats (weighing ۱۸۰-۲۰۰ gr, aged ۱۰-۱۲ week) were divided into six groups (n = ۷/each): control; PCOS; RJ ۱۰۰ mg/kg; RJ ۲۰۰ mg/kg; PCOS + RJ ۱۰۰ mg/kg; and PCOS + RJ ۲۰۰ mg/kg. After ۲۱ days, the animals were weighed and dissected. The serums were used for nitric oxide (NO) and ferric-reducing antioxidant power (FRAP) assay and estradiol and progesterone measurements. The ovaries were assessed for histological changes. Results: PCOS increased estradiol and NO levels, and decreased progesterone and FRAP levels. In PCOS+ RJ groups, the progesterone (p  =۰.۰۱) and FRAP levels (p ≤ ۰.۰۰۱) increased and the estradiol and NO (p ≤ ۰.۰۰۱) levels decreased significantly. Moreover, the number of mature follicles (p = ۰.۰۱) and corpus luteum increased (p ≤ ۰.۰۰۱), and ovarian and uterus weight deceased significantly (p ≤ ۰.۰۰۱). Conclusion: RJ improved estradiol, progesterone, FRAP, and NO levels, and ovarian structure in the rat model of PCOS.

Keywords:

Royal jelly , Polycystic ovary syndrome , Ovary , Sex hormone. , ژل رویال , سندرم تخمدان پلی کیستیک , تخمدان , هورمون جنسی.