Fatemeh Khazaei - Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Elham Ghanbari - Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Mozafar Khazaei - Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background: Polycystic ovarian syndrome (PCOS) is an endocrine and complex metabolic disorder, associated with anovulation, changes in sex hormone, biochemical factors, and ovarian tissue. Royal jelly (RJ) has antioxidant and anti-inflammatory properties. Objective: To examine the therapeutic effect of RJ on PCOS-related hormonal and biochemical changes in a rat model of PCOS. Materials and Methods: In this experimental study, ۴۲ female Wistar rats (weighing ۱۸۰-۲۰۰ gr, aged ۱۰-۱۲ week) were divided into six groups (n = ۷/each): control; PCOS; RJ ۱۰۰ mg/kg; RJ ۲۰۰ mg/kg; PCOS + RJ ۱۰۰ mg/kg; and PCOS + RJ ۲۰۰ mg/kg. After ۲۱ days, the animals were weighed and dissected. The serums were used for nitric oxide (NO) and ferric-reducing antioxidant power (FRAP) assay and estradiol and progesterone measurements. The ovaries were assessed for histological changes. Results: PCOS increased estradiol and NO levels, and decreased progesterone and FRAP levels. In PCOS+ RJ groups, the progesterone (p  =۰.۰۱) and FRAP levels (p ≤ ۰.۰۰۱) increased and the estradiol and NO (p ≤ ۰.۰۰۱) levels decreased significantly. Moreover, the number of mature follicles (p = ۰.۰۱) and corpus luteum increased (p ≤ ۰.۰۰۱), and ovarian and uterus weight deceased significantly (p ≤ ۰.۰۰۱). Conclusion: RJ improved estradiol, progesterone, FRAP, and NO levels, and ovarian structure in the rat model of PCOS.

Royal jelly, Polycystic ovary syndrome, Ovary, Sex hormone., ژل رویال, سندرم تخمدان پلی کیستیک, تخمدان, هورمون جنسی.