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Title

Association of M۵۵L and Q۱۹۲R polymorphisms of paraoxonase ۱ gene (PON۱) with recurrent pregnancy loss risk: A case-control study

Year: 1400
COI: JR_IJRM-19-6_007
Language: EnglishView: 118
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Authors

Mehdi Alizadeh - International Campus, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mahboobeh Nasiri - Department of Biology, Islamic Azad University, Arsanjan Branch, Arsanjan, Iran.
Morteza Samadi - Department of Immunology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
Nasrin ghasemi - Abortion Research Centre, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Ali Moradi - Department of Clinical Biochemistry, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.

Abstract:

Background: Recurrent pregnancy loss (RPL) refers to the incidence of two or more abortions before the first half of pregnancy. Oxidative stress has been hypothesized to play a central role in RPL. Objective: To investigate the relationship between Q۱۹۲R and L۵۵M polymorphisms of PON۱ as antioxidant enzyme and the risk of RPL. Materials and Methods: In this case-control study, ۱۱۰ women with RPL (case) and ۱۱۰ healthy fertile women (control) referred to the Research and Clinical Center for Infertility, Shiraz, Iran were enrolled. Genomic DNA was extracted from the peripheral blood in all participants. Polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism method. Results: Statistical analysis of Q۱۹۲R polymorphism showed a significant difference for the RR genotype between the case and control group (OR = ۱۱, CI = ۱.۳۹-۸۶.۸۷, p = ۰.۰۰۵) but none for the QR and QQ genotypes. No significant association was observed between the R and Q allelic frequency in the RPL participants compared to the control group (p = ۰.۵۳). Also, statistical analysis of the L۵۵M polymorphism for MM genotype in the case group compared with the control group showed a significant difference (OR = ۳.۵۹, CI = ۰.۹۷-۱۳.۳۰, p = ۰.۰۴۲), but none for the LM and LL genotypes. Conclusion: The findings showed a significant correlation between the Q۱۹۲R polymorphisms and the L۵۵M PON۱ enzyme and RPL in this study population.

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This Paper COI Code is JR_IJRM-19-6_007. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1249839/

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Alizadeh, Mehdi and Nasiri, Mahboobeh and Samadi, Morteza and ghasemi, Nasrin and Moradi, Ali,1400,Association of M۵۵L and Q۱۹۲R polymorphisms of paraoxonase ۱ gene (PON۱) with recurrent pregnancy loss risk: A case-control study,https://civilica.com/doc/1249839

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