A Brief Study of a Comprehensive Meta-Analysis Study of the Birth Outcomes of Corona Mothers in Iran

Many questions pertaining to the neonates born to the mothers affected by Covid۱۹ have arisen, particularly with regard to the likelihood of vertical transmission of the virus, the association between the intensity of disease in mothers and severity of neonatal morbidities. The present systematic review and meta-analysis attempted to deliver the responses to such uncertainties. For statistical analysis, the Comprehensive Meta-Analysis Software was employed. Overall, ۱۶ studies including ۱۱۹۲ mothers with the average age of ۳۱ years suffering definitive diagnosis of Covid-۱۹ and delivered successfully were assessed with respect to their clinical manifestations as well as pregnancy and neonatal outcome. The median of birth weight was ۳۰۸۰ gr. The pooled cesarean rate was ۴۸.۳%. Respecting neonatal outcome, neonatal respiratory distress was overall revealed in ۱۳.۱% (۹۵%CI: ۱۰.۶% to ۱۶.۰%) and in total, ۲۰.۱% (۹۵%CI: ۱۷.۶% to ۲۰.۳%) required NICU admission. Overall, ۳.۸% (۹۵%CI: ۲.۶% to ۵.۷%) of the neonates tested positive for SARS-CoV-۲ infection, while no neonatal death was reported in all the studies. The rate of vertical transmission of SARS-CoV-۲ infection from mother to neonate is very low and overall outcome reported in these infants is quite favorable. Thus, encouraging immediate bonding, rooming-in and breastfeeding should be considered for all neonates born to infected mothers.

Keywords:

Mothers , SARS-CoV-۲ , Pooled Cesarean Rate , Comprehensive Meta-Analysis , Meta-analysis