The administration of interferon-beta۱b and favipiravir in patients with COVID-۱۹ pneumonia

Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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JR_TIPS-7-2_007

تاریخ نمایه سازی: 20 مرداد 1400

Abstract:

Purpose: To assess the efficacy of interferon-beta۱b (INF-beta۱b) in combination with favipiravir in early treatment of patients with COVD-۱۹ pneumonia. Methods: This prospective non-controlled study was performed on admitted patients with moderate to severe COVID-۱۹ disease to Amir-Alam hospital. The diagnosis of COVID-۱۹ pneumonia was based on positive RT-PCR test from nasopharyngeal samples and typical spiral chest CT scan findings. At the time of this study, there was the shortage of efficient anti-COVID drugs especially “Remdesivir” due to sanction of Iran. All the patients received subcutaneous IFN-beta۱b plus favipiravir. The patients with severe infection received intravenous dexamethasone. Those who underwent invasive or noninvasive mechanical ventilation, at the admission onset, were excluded from the study. Results: One hundred and eighty-two patients with moderate to severe COVID-۱۹ pneumonia were included in this study. Among۱۸۲ patients, ۹۰ cases had moderate and ۹۲ had severe pneumonia. Twenty-one cases with severe pneumonia and ۱۴ cases with moderate pneumonia were transferred to ICU to receive invasive or non-invasive mechanical ventilation. The mean duration of hospital ward admission and ICU stay was ۱۰.۶۹±۷.۵۴ and ۵.۴۵±۲.۷۲ days, respectively. One hundred and seventy-four patients (۸۰.۷ %) recovered completely and discharged without need to ICU admission. The response rate was the same in patients with moderate and severe pneumonia. Nine cases (۴.۹ %) were passed away. Diabetic patients had higher mortality rates. Conclusion: This study showed the efficacy of IFN-beta۱b plus favipiravir in early treatment of patients with moderate to severe COVID-۱۹ pneumonia who did not need to mechanical ventilation.

Authors

Mehrdad Hasibi

Department of Infectious Diseases, Amir Alam Hospital, Tehran University of Medical Sciences, Tehran,Iran

Ali Asadollahi-Amin

Department of Infectious Diseases, Amir Alam Hospital, Tehran University of Medical Sciences, Tehran,Iran

Nozhat Besharati

Department of Infectious Diseases, Amir Alam Hospital, Tehran University of Medical Sciences, Tehran,Iran

Farahnaz Salehinia

Department of Internal Medicine, Amir Alam Hospital, Tehran University Of Medical Sciences, Tehran, Iran

Maryam Khoshnevis

Department of Internal Medicine, Amir Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran

Saiedeh Ahmadi

Department of Internal Medicine, Amir Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran

Sima Maziar

Department of Internal Medicine, Amir Alam Hospital, Tehran University Of Medical Sciences, Tehran, Iran

Goli Siri

Department of Internal Medicine, Amir Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran

Maryam Moosivand Darani

Department of Internal Medicine, Amir Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran

Maryam Taghizadeh

Department of Internal Medicine, Amir Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran

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