Does curcumin have an effect on sleep duration in metabolic syndrome patients?

Objective: Sleep-duration is related to obesity. Curcumin can affect behavioral changes that arise from sleep deprivation in animal models. In this study, we assessed the effects of curcumin on sleep-duration in metabolic-syndrome (MetS) patients. Materials and Methods: This study was a double-blind clinical trial in ۱۲۰ adults with MetS. All participants received crude curcuminoids in a simple formulation (n=۴۰), phospholipidated curcuminoids (n=۴۰) or placebo (n=۴۰) ۱ g/day during ۶ weeks. Demographic data, anthropometric indices and serumbiochemical factors were documented forall volunteers at baseline and after the intervention. A standard questionnaire was used for evaluating physical-activity-level (PAL) and patients’ sleep-duration, including night time sleep and daily napping. Based on the time of sleep, sleeping hours were classified into: night time sleep; daily naps and total sleeping hours in ۲۴ hours. Results: A total of ۱۲۰ participants aged ۳۸.۷۲±۱۰.۰۵ years old were enrolled into the study. We did not find significant differences in biochemical factors, sleep-duration or PAL at baseline among the ۳ groups (p>۰·۰۵). Moreover,curcumin did not exert any significant effect on sleep-duration before, or after, adjustment for confounding factors in the overweight and obese individuals, or in total population (p>۰.۰۵). Conclusion: The results showed that curcumin does not have an effect on sleep-duration in subject with MetS.

Keywords:

Curcumin , metabolic syndrome , sleep duration