Antihyperglycemic, antihyperlipidemic and hepatoprotective effects of Ficus ottoniifolia (Miq.) Miq. supplementation in alloxan-induced diabetic rats

Objective: Medicinal plants provide better and cheaper alternative therapy for management of several diseases compared to orthodox medicines. This study evaluated the effects of feed formulated with Ficus ottoniifolia (Miq.) Miq. (FFFO) leaves in the management of alloxan-induced diabetes mellitus (DM) in rats. Materials and Methods: DM was induced in overnight-fasted rats by administration of alloxan monohydrate intraperitoneally. DM rats in Groups ۱−۳ were fed with graded FFFO while group ۴ (diabetic control) and group ۵ (normal control) were fed with commercial feeds (Vital-Feeds), daily for ۲۱ days. Changes in body weight and some biochemical parameters were thereafter determined. Results: Results showed significant decreases (p <۰.۰۵) in serum high-density lipoprotein (HDL) but significant increases (p <۰.۰۵) in blood glucose, serum low-density lipoprotein (LDL), triglyceride (TG), total cholesterol (TC) and alanine aminotransferase (ALT) activities in DM-induced rats compared to the normal control group. Feeding with FFFO significantly increased (p <۰.۰۵) the body weight and HDL, decreased the blood glucose, serum LDL, TG and TC and attenuated ALT activities in FFFO-fed DM rats compared to the diabetic control group. Conclusion: This study revealed that FFFO-diet may mitigate hyperglycemia, dyslipidemia and liver-damage associated with DM.

Keywords:

Alloxan , Diabetes , Ficus ottoniifolia , Hepatoprotective , Hyperglycemia , supplemented diet