Sahar heidari - Graduate student of Biology, Department of Biology, Science and research Branch, Islamic Azad University, Tehran, Iran.
soheila abdi - Assistant Professor, Department of Physics, Safadasht Branch, Islamic Azad University, Tehran, Iran.
Shohreh Zare Karizi - Assistant Professor, Department of Genetics, School of Biological Sciences, Varamin-Pishva Branch, Islamic Azad university, Varamin, Iran.

In this research, changes in the expression of BCL۲, miR-۱۵-b, and miR-۱۶ in human gastric cell line (AGS) following the exposure to magnetic flux densities (MFDs) of ۰.۲ and ۲ mT for ۱۸ h were investigated. Changes in the cell viability were evaluated by MTT assay. Real-time PCR was used to evaluate the expression changes of BCL۲, miR-۱۵-b, and miR-۱۶. The results showed that ELF-EMF could significantly reduce the viability of AGS cells in the continuous MFD of ۲ mT. The BCL۲ expression was significantly decreased following the exposure to continuous MFDs of ۰.۲ and ۲ mT and discontinuous MFD of ۲ mT. The expression of miR-۱۵-b, and miR-۱۶ was significantly increased in continuous and discontinuous MFD of ۲ mT. According to the results, weak and moderate ELF-EMFs can change the expression of BCL۲, miR-۱۵-b, and miR-۱۶.

Electromagnetic fields; Adenocarcinoma gastric cell line (AGS); MiR-۱۵-b; miR۱۶; BCL۲