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Title

Molecular Docking, Drug likeness Studies and ADMET prediction of Flavonoids as Platelet-Activating Factor (PAF) Receptor Binding

مقالات مروری و پژوهشی شیمی، دوره: 4، شماره: 3
Year: 1400
COI: JR_CHRL-4-3_002
Language: EnglishView: 41
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Authors

Mohammed BOUACHRINE - b p ۱۱۲۰۱، Avenue Zitoune, Meknes, Morocco
Larbi Elmchichi - Faculty of Science, Moulay Ismail University of Meknes, Morocco
Abdellah El Aissouq - Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, Fez, Morocco
Assia BELHASSAN - Faculty of Science, Moulay Ismail University of Meknes, Morocco
Hanane Zaki - EST Khenifra, Sultan Moulay Sliman University, Benimellal, Morocco
Abdelkrim Ouammou - Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, Fez, Morocco
Tahar Lakhlifi - Faculty of Science, Moulay Ismail University of Meknes, Morocco

Abstract:

Studies and scientific research indicate that the platelet-activating factor (PAF) is a major pro-inflammatory mediator in the initiation and development of cancer. There is also evidence confirming that PAF is an integral part of suppressing the immune system and promoting the appearance of a malignant tumor. For this reason, it is useful to analyze the molecular docking data of eleven flavonoids derivatives isolated from the active leaf extracted from chromolaena odorata with their anti-PAF activity. As a result, it is evident that the natural product of flavonoids may have a positive effect in the development of both therapeutic and preventive agents for platelet activating factor (PAF) antagonist and suggests potential guidelines for the design of PAF inhibitors. Based on the docking score analysis, drug likeness study, and ADMET prediction. We found that six compounds respect all drug-likeness rules and can be used as a potent molecule for inhibition of platelet activating factor (PAF).

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This Paper COI Code is JR_CHRL-4-3_002. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1259923/

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If you want to refer to this Paper in your research work, you can simply use the following phrase in the resources section:
BOUACHRINE, Mohammed and Elmchichi, Larbi and El Aissouq, Abdellah and BELHASSAN, Assia and Zaki, Hanane and Ouammou, Abdelkrim and Lakhlifi, Tahar,1400,Molecular Docking, Drug likeness Studies and ADMET prediction of Flavonoids as Platelet-Activating Factor (PAF) Receptor Binding,https://civilica.com/doc/1259923

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