ناشر تخصصی کنفرانس های ایران

لطفا کمی صبر نمایید

Publisher of Iranian Journals and Conference Proceedings

Please waite ..
Publisher of Iranian Journals and Conference Proceedings
Login |Register |Help |عضویت کتابخانه ها
Paper
Title

The effect of niosome nanoparticles encapsulating stevia extract on the expression of TNF- a and IL-۶ genes in type۲ diabetic model induced by intravenous injection of streptozotocin in male rats

Year: 1399
COI: BIOCONF21_0675
Language: EnglishView: 63
نسخه کامل این Paper ارائه نشده است و در دسترس نمی باشد

Authors

Elham Ghanimati - Department of Cellular and Molecular Biology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Fatemeh Khakpai - Assistant Professor of Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences, Islamic Azad. University, Tehran, Iran
Neda Mousavi Niri - Department of Medical Biotechnology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Maryam Naseroleslami - Cellular and Molecular Biology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

Abstract:

Today, diabetes has spread and the drugs used so far have not been completely effective. Therefore, although natural compounds have fewer side effects than chemical compounds, the treatment of diabetes has advanced towards these methods. Therefore, the aim of this research project is to use Stevia Newsome to increase drug efficacy in male diabetic rat models. The purpose of this study was to the effect of niosome nanoparticles encapsulating stevia extract on the expression of TNF- a and IL-۶ genes in type۲ diabetic model induced by intravenous injection of streptozotocin in male rats. In this study, ۴۰ Wistar rats with an average weight of ۲۰۰-۲۵۰ g were used. They were divided into ۴ groups including healthy control, diabetic control (sham), stevia, and niosome stevia. Mice received daily stevia and niosome stevia at a dose of ۵۰۰ mg / kg by gavage for ۳۰ days after diabetes. Forty-eight hours after the last treatment time, the rats in each group were anesthetized and their liver tissue was removed and real-time PCR was performed to examine the TNf- a and IL-۶ genes. Streptozotocin injection significantly increases blood sugar compared to the control group. Injection of stevia with nanoniosome also reduced blood sugar to the control group (p <۰.۰۰۱). Decreased expression of inflammatory factors (TNF- a and IL-۶) (P <۰.۰۱). It can be stated that one of the effects of stevia is the effect on gene expression and the improvement of diabetes, and during this study, the groups that received the drug in the form of niosome further improved this and reduced the expression of the gene. Niosome also produces a better and more effective effect.

Keywords:

Diabetes - Stevia – TNF-a gene – IL-۶ gene –Stevia

Paper COI Code

This Paper COI Code is BIOCONF21_0675. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1260641/

How to Cite to This Paper:

If you want to refer to this Paper in your research work, you can simply use the following phrase in the resources section:
Ghanimati, Elham and Khakpai, Fatemeh and Mousavi Niri, Neda and Naseroleslami, Maryam,1399,The effect of niosome nanoparticles encapsulating stevia extract on the expression of TNF- a and IL-۶ genes in type۲ diabetic model induced by intravenous injection of streptozotocin in male rats,21th National & 9th International Congress on Biology,https://civilica.com/doc/1260641

Research Info Management

Certificate | Report | من نویسنده این مقاله هستم

اطلاعات استنادی این Paper را به نرم افزارهای مدیریت اطلاعات علمی و استنادی ارسال نمایید و در تحقیقات خود از آن استفاده نمایید.

New Papers

Share this page

More information about COI

COI stands for "CIVILICA Object Identifier". COI is the unique code assigned to articles of Iranian conferences and journals when indexing on the CIVILICA citation database.

The COI is the national code of documents indexed in CIVILICA and is a unique and permanent code. it can always be cited and tracked and assumed as registration confirmation ID.

Support