ناشر تخصصی کنفرانس های ایران

لطفا کمی صبر نمایید

Publisher of Iranian Journals and Conference Proceedings

Please waite ..
Publisher of Iranian Journals and Conference Proceedings
Login |Register |Help |عضویت کتابخانه ها
Paper
Title

Benzodiazepine Toxicity Treatment: A Comparative Molecular Docking study of flumazenil and diazepam

Year: 1399
COI: BIOCONF21_0687
Language: EnglishView: 20
نسخه کامل این Paper ارائه نشده است و در دسترس نمی باشد

Authors

Hooman Barati Bourojeni - Department of Biochemistry, Islamic Azad University of Medical Sciences, Tehran, Iran
Seyed Mohammad Masoud Shoshtarian - Department of Biochemistry, Islamic Azad University of Medical Sciences, Tehran, Iran
Raheleh Jahanbani - Institute of Biochemistry and Biophysics, University of Tehran, Tehran. Iran

Abstract:

Epilepsy is a set of chronic or long-term neurological disorders characterized by an epileptic seizure. Epilepsy is one of the most common neurological diseases in Iran and its prevalence is higher than the world standard. Scientific studies show that about one to one and a half percent of Iranians have epilepsy, which indicates that epileptic patients in Iran are about three times more than in Europe. Flumazenil is a benzodiazepine antidote and is used to treat benzodiazepine poisoning, but studies show that people who take the drug have an increased risk of seizures, a symptom of epilepsy. Different concentrations of diazepam and flumazenil were injected into mice at different intervals to obtain the effective dose and effective time of action of each drug. In this study, it is demonstrated that a concentration of ۰.۷۵ mg / kg of flumazenil can decrease the threshold of induced seizures with PTZ to control value. But concentrations higher than this value reduce the threshold for induction of seizures more than control group and therefore reduce the dose of PTZ.The molecular docking studies identify the binding site of these two drugs on the GABA receptor and show that flumazenil can act as an inhibitor at a site close to the diazepam binding site and neutralize its action.

Keywords:

Paper COI Code

This Paper COI Code is BIOCONF21_0687. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1260653/

How to Cite to This Paper:

If you want to refer to this Paper in your research work, you can simply use the following phrase in the resources section:
Barati Bourojeni, Hooman and Shoshtarian, Seyed Mohammad Masoud and Jahanbani, Raheleh,1399,Benzodiazepine Toxicity Treatment: A Comparative Molecular Docking study of flumazenil and diazepam,21th National & 9th International Congress on Biology,https://civilica.com/doc/1260653

Research Info Management

Certificate | Report | من نویسنده این مقاله هستم

اطلاعات استنادی این Paper را به نرم افزارهای مدیریت اطلاعات علمی و استنادی ارسال نمایید و در تحقیقات خود از آن استفاده نمایید.

Scientometrics

The specifications of the publisher center of this Paper are as follows:
Type of center: Azad University
Paper count: 973
In the scientometrics section of CIVILICA, you can see the scientific ranking of the Iranian academic and research centers based on the statistics of indexed articles.

New Papers

Share this page

More information about COI

COI stands for "CIVILICA Object Identifier". COI is the unique code assigned to articles of Iranian conferences and journals when indexing on the CIVILICA citation database.

The COI is the national code of documents indexed in CIVILICA and is a unique and permanent code. it can always be cited and tracked and assumed as registration confirmation ID.

Support