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Paper
Title

Evaluation of the Nanoparticles Containing Tyrosol Effect on the Expression of GLUT۲ and GLUT۹ Genes in Diabetic Rats

Year: 1399
COI: BIOCONF21_0718
Language: EnglishView: 18
نسخه کامل این Paper ارائه نشده است و در دسترس نمی باشد

Authors

Haniyeh Sadat Hosseininia - Department of Cellular and Molecular Biology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Fatemeh Khakpai - Assistant Professor of Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Neda Mousavi Niri - Department of Medical Biotechnology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Maryam Naseroleslami - Department of Cellular and Molecular Biology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

Abstract:

Diabetes, a metabolic disease with decreased insulin secretion or insulin insufficiency and high blood sugar, has three different types, and about ۹۰ percent of type ۲ diabetes. Given the destruction of the International Diabetes Association (IDF), which will increase the number of patients to ۵۹۲ million by ۲۰۲۵, it is crucial to address the challenge of treating type ۲ diabetes (۱, ۲, ۳). High blood sugar is one of the aggravating factors of this disease, and so far, the conventional treatment strategies have not been effective in transferring glucose into the cell. GLUT۲ and GLUT۹ are facilitated membrane glucose transporter that facilitates blood glucose release through the kidney, liver, and placenta's plasma membrane. In addition to its anti-inflammatory and antioxidant properties, tyrosol has been shown to have insulin-like functional properties that face the challenge of targeted cell delivery. Niosome carriers; or nonionic surfactant vesicles can be valuable in the targeted delivery of tyrosol to the cell . In this study, Niosome carriers' function in targeted tyrosol transfer to rat hepatocytes was evaluated by measuring the expression of GLUT۲ and GLUT۹ genes. For this purpose, diabetic rats were divided into five groups: control, diabetic, nanoniosome, tyrosol and nanotyrosol and were treated for ۴۵ days. After dissection and extraction of liver tissue, the expression of GLUT۲ and GLUT۹ genes was measured by real-time PCR. The nanotyrosol and tyrosol groups showed the highest gene expression, respectively.

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Paper COI Code

This Paper COI Code is BIOCONF21_0718. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1260684/

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If you want to refer to this Paper in your research work, you can simply use the following phrase in the resources section:
Hosseininia, Haniyeh Sadat and Khakpai, Fatemeh and Mousavi Niri, Neda and Naseroleslami, Maryam,1399,Evaluation of the Nanoparticles Containing Tyrosol Effect on the Expression of GLUT۲ and GLUT۹ Genes in Diabetic Rats,21th National & 9th International Congress on Biology,https://civilica.com/doc/1260684

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