Evaluation of antibacterial properties and wound healing ointment based on curcumin and honey

Wounds from various burns can severely impair the life quality of patients. The use of natural compounds in the treatment of various diseases has long been considered. Curcumin and honey have been used as traditional wound-healing medicines in some ancient civilizations. The study aimed to investigate the synergistic healing properties of these substances as a novel burn ointment in secondary burn wounds. In this study, MIC۵۰ and MIC۹۹ use of curcumin and honey on ۲۰۰ clinical isolates of Pseudomonas aeruginosa were compared with imipenem in vitro. Their killing time and cytotoxicity were also studied using standard P. aeroginosa isolates, fibroblast stem cells, and mouse embryonic fibroblasts, respectively. Then, ۱۵۰ male Wistar rats weighing between ۲۸۰ and ۳۰۰ gr were divided into four experimental groups receiving a newly prepared burn ointmentcontaining honey and curcumin, ointment base, zinc oxide ointment, and no treatment as the control for ۳ weeks on the experimentally induced burn wounds. Histopathological and histomorphological assessments were then conducted on the injured area to evaluate the efficiency of the prepared burn ointment MIC۵۰ and MIC۹۹ against P. aeruginosa were at least ۶۴ and ۱۲۸ μg mL-۱ for imipenem, ۱۶ and ۳۲ μg mL-۱ for curcumin, and ۸ and ۱۶ μg mL-۱ for honey. Histopathological results showed wound re-epithelialization According to the results, it can be claimed that burn ointment containing honey and curcumin has a significant effect on accelerating the healing of burn wounds.

Keywords:

Wounds , Second-degree burns , Medicinal plants , Burn healing