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Title

MKK۴ variants rs۳۸۲۶۳۹۲ and rs۳۸۰۹۷۲۸ are associated with susceptibility and clinicopathological features in colorectal cancer patients

Year: 1400
COI: JR_IJBMS-24-8_004
Language: EnglishView: 47
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Authors

Kimberly Martínez-Casillas - División de Medicina Molecular, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, México
Anilú Margarita Saucedo-Sariñana - División de Medicina Molecular, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, México
Patricio Barros-Núñez - Unidad de Investigación Seguimiento Enfermedades Metabólicas, Unidad Médica de Alta Especialidad Pediatría, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco. México
Martha Patricia Gallegos Arreola - División de Genética, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, México
Tomas Daniel Pineda Razo - Servicio de Oncología Médica, Hospital de Especialidades, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, México
María Eugenia Marín-Contreras - Servicio de Gastroenterología, Hospital de Especialidades, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, México
Silvia Esperanza Flores-Martínez - División de Medicina Molecular, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, México
Mónica Alejandra Rosales-Reynoso - División de Medicina Molecular, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, México

Abstract:

Objective(s): The mitogen-activated protein kinase kinase ۴ (MKK۴) plays a key role in several processes like inflammation, apoptosis, and tumorigenesis. Several authors have proposed that genetic variations in these genes may alter their expression with subsequent cancer risk. This study aimed to examine the possible association of MKK۴ rs۳۸۲۶۳۹۲ and rs۳۸۰۹۷۲۸ variants in Mexican patients with colorectal cancer (CRC). These variants were also compared with clinical features as sex, age, TNM stage, and tumor location.Materials and Methods: The study included genomic DNA from ۲۱۸ control subjects and ۲۵۰ patients. Genotyping of the MKK۴ variants was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) procedure. Results: Individuals with A/T and T/T genotypes for the rs۳۸۰۹۷۲۸ (-۱۰۴۴ A>T) variant showed a significantly increased risk for CRC (P=۰.۰۱۲ and ۰.۰۰۷, respectively); while individuals with the G/G genotype for the rs۳۸۲۶۳۹۲ (-۱۳۰۴ T>G) variant showed a decreased risk for CRC (P=۰.۰۱۲). Genotypes of the MKK۴ rs۳۸۰۹۷۲۸ variant were also significantly related to colon localization and advanced TNM stage in CRC patients. T-T haplotype (rs۳۸۲۶۳۹۲ and rs۳۸۰۹۷۲۸) of the MKK۴ gene was associated with risk in patients with CRC.Conclusion: The rs۳۸۲۶۳۹۲ variant in the MKK۴ gene could be a cancer protective factor, while the rs۳۸۰۹۷۲۸ variant could be a risk factor. These variants play a significant role in CRC risk.

Keywords:

Paper COI Code

This Paper COI Code is JR_IJBMS-24-8_004. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1262945/

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If you want to refer to this Paper in your research work, you can simply use the following phrase in the resources section:
Martínez-Casillas, Kimberly and Saucedo-Sariñana, Anilú Margarita and Barros-Núñez, Patricio and Gallegos Arreola, Martha Patricia and Pineda Razo, Tomas Daniel and Marín-Contreras, María Eugenia and Flores-Martínez, Silvia Esperanza and Rosales-Reynoso, Mónica Alejandra,1400,MKK۴ variants rs۳۸۲۶۳۹۲ and rs۳۸۰۹۷۲۸ are associated with susceptibility and clinicopathological features in colorectal cancer patients,https://civilica.com/doc/1262945

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