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Title

Investigating PIK۳R۳ and ATp۲A۱ Genes Expressions in Ventilator-Associated Pneumonia Patients Admitted to the Intensive Care Unit of Masih Daneshvari Hospital in ۲۰۱۶

مجله گزارش های بیوشیمی و زیست شناسی مولکولی، دوره: 6، شماره: 2
Year: 1397
COI: JR_RBMB-6-2_001
Language: EnglishView: 53
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Authors

Hamidreza Jamaati - Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Naghmeh Bahrami - Craniomaxillofacial Research center, Tehran University of Medical Sciences, Tehran, Iran. Oral and Maxillofacial Surgery Department, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
Mahya Daustany - Department of Biotechnology, Faculty of Sciences, Islamic Azad University, Tehran, Iran.
Payam Tabarsi - Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Behrooz Farzanegan - Tracheal Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Seyed Mohammadreza Hashemian - Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abdolreza Mohamadnia - Virology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti Unive

Abstract:

Background: Infectious diseases such as ventilator- associated pneumonia (VAP) are one of the serious problems in intensive care units (ICU) of hospitals. To date, there has been no appropriate clinical and diagnostic marker for early detection of this disease. In this study, expression of PIK۳R۳ and ATp۲A۱ genes in patients with VAP were assessed to be used as biomarkers to identify and confirm the disease. Methods: This study was conducted by using peripheral blood samples of ۶۰ individuals, including ۳۰ patients with VAP and ۳۰ healthy volunteers. First, the peripheral blood samples were taken and then RNA was extracted and converted into cDNA. Finally, the assessment of genes was performed by Real-time PCR. Results: In peripheral blood samples, ۴۶.۶% and ۳۰% were positive for PIK۳R۳ expression in patients and healthy groups, respectively. The ATp۲A۱ expression in patients and healthy controls were found ۴۰% and ۲۳.۳%, respectively. Comparing the ΔCT obtained for the PIK۳R۳ and ATp۲A۱ genes showed statistically significant differences between the two groups of patients and healthy subjects (p=۰.۰۴۲, p=۰.۰۳۶). Conclusions: ATp۲A۱ and PIK۳R۳ may be used as biomarkers for early detection of VAP disease. However, further studies are required.

Keywords:

ATp , A , gene , PIK , R , gene , Ventilator- associated pneumonia (VAP).

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This Paper COI Code is JR_RBMB-6-2_001. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1262999/

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Jamaati, Hamidreza and Bahrami, Naghmeh and Daustany, Mahya and Tabarsi, Payam and Farzanegan, Behrooz and Hashemian, Seyed Mohammadreza and Mohamadnia, Abdolreza,1397,Investigating PIK۳R۳ and ATp۲A۱ Genes Expressions in Ventilator-Associated Pneumonia Patients Admitted to the Intensive Care Unit of Masih Daneshvari Hospital in ۲۰۱۶,https://civilica.com/doc/1262999

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Type of center: علوم پزشکی
Paper count: 5,360
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